Facile Synthesis of <i>N</i>-(4-Bromo-3-methylphenyl)pyrazine-2-carboxamide Derivatives, Their Antibacterial Activities against Clinically Isolated XDR <i>S. Typhi</i>, Alkaline Phosphatase Inhibitor Activities, and Docking Studies

Facile Synthesis of <i>N</i>-(4-Bromo-3-methylphenyl)pyrazine-2-carboxamide Derivatives, Their Antibacterial Activities against Clinically Isolated XDR <i>S. Typhi</i>, Alkaline Phosphatase Inhibitor Activities, and Docking Studies

The emergence of extensively drug-resistant <i>Salmonella</i> Typhi (XDR-<i>S. Typhi</i>) poses a grave public health threat due to its resistance to fluoroquinolones and third-generation cephalosporins. This resistance significantly complicates treatment options, underscorin...

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Bibliographic Details
Main Authors: Abdul Hannan Khan, Muhammad Bilal, Abid Mahmood, Nasir Rasool, Muhammad Usman Qamar, Muhammad Imran, Sebastian Ionut Toma, Oana Andreescu
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Pharmaceuticals
Subjects:
pyrazine-2-carboxamides
XDR <i>S. Typhi</i>
alkaline phosphatase inhibitors
drug resistance
docking studies
Online Access:https://www.mdpi.com/1424-8247/17/9/1241
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