Covariation of scleral remodeling and PI3K/Akt signaling pathway in experimental myopia

Covariation of scleral remodeling and PI3K/Akt signaling pathway in experimental myopia

Abstract The present study aimed to investigate the role of the PI3K/Akt signaling pathway in scleral remodeling in the development of negative lens-induced myopia (LIM). The change of scleral morphology in experimental myopic guinea pigs was observed by transmission electron microscopy, Masson stai...

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Main Authors: Xiaomeng Li, Xiaojing Liu, Yingxin Yu, Tuling Li, Lijie Guo, Guili Hu, Huixia Wei, Zhaohui Yang, Jinpeng Liu, Yixian Hao, Ruixue Zhang, Qiuxin Wu, Xuan Liao, Dadong Guo, Hongsheng Bi
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Experimental myopia
PI3K/Akt signaling pathway
TGF-β1
Collagen
Scleral remodeling
Online Access:https://doi.org/10.1038/s41598-025-97643-7
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https://doi.org/10.1038/s41598-025-97643-7

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