Evaluation of the anti-diabetic effects of Commelina diffusa on testicular tissue of male Wistar rats
Background: Diabetes mellitus is a metabolic illness defined by elevated blood sugar levels caused by insulin deficit or resistance, as well as structural and functional problems in several organs. Aim and Objectives: This study assesses the efficacy of Commelina diffusa Extract (CDE) on the reprod...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2025-01-01
|
| Series: | Journal of Krishna Institute of Medical Sciences University |
| Subjects: | |
| Online Access: | https://www.jkimsu.com/jkimsu-vol14no1/JKIMSU,%20Vol.%2014,%20No.%201,%20January-March%202025%20Page%2040-48.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849224350595547136 |
|---|---|
| author | Efe Jennifer Jaiyeoba-Ojigho Lilian Ebele Chris-Ozoko Efemena Amarere Ikechukwu Emmanuel Okolie Tejiri Opiri |
| author_facet | Efe Jennifer Jaiyeoba-Ojigho Lilian Ebele Chris-Ozoko Efemena Amarere Ikechukwu Emmanuel Okolie Tejiri Opiri |
| author_sort | Efe Jennifer Jaiyeoba-Ojigho |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a metabolic illness defined by elevated blood sugar levels caused by insulin deficit or resistance, as well as structural and functional problems in several organs. Aim and Objectives: This study assesses the
efficacy of Commelina diffusa Extract (CDE) on the reproductive functions of diabetic male Wistar rats. Material and Methods: Thirty mature male Wistar rats were grouped into five groups of five rats each. Group 1: Normal control
group; Group 2: High Fat Diet (HFD) + Streptozotocin (STZ); Group 3: HFD + STZ + 300mg/kg CDE; Group 4: HFD + STZ + 600 mg/kg CDE; Group 5: HFD + STZ + 1200 mg/kg CDE. All treatments were carried out for 21 days. On 22nd day of the experiment, after an overnight fast, the experimental rats were sacrificed via cervical dislocation, and the testicular tissues were collected for biochemical, hormonal, and semen quality examination. The study found a substantial drop (p < 0.05) in antioxidant activity, male sex hormones, and sperm quality. Treatment with CDE significantly repaired the damage caused by diabetes. Conclusion: CDE is efficient in reducing oxidative stress, increasing antioxidant defense, improving reproductive hormone balance, and preserving male reproductive health in
the face of poor metabolic circumstances. |
| format | Article |
| id | doaj-art-359e365a9f6843dc88e8b4534c7abfb3 |
| institution | Kabale University |
| issn | 2231-4261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Krishna Vishwa Vidyapeeth (Deemed to be University), Karad |
| record_format | Article |
| series | Journal of Krishna Institute of Medical Sciences University |
| spelling | doaj-art-359e365a9f6843dc88e8b4534c7abfb32025-08-25T10:35:50ZengKrishna Vishwa Vidyapeeth (Deemed to be University), KaradJournal of Krishna Institute of Medical Sciences University2231-42612025-01-011414048Evaluation of the anti-diabetic effects of Commelina diffusa on testicular tissue of male Wistar ratsEfe Jennifer Jaiyeoba-Ojigho0Lilian Ebele Chris-Ozoko1Efemena Amarere2Ikechukwu Emmanuel Okolie3Tejiri Opiri4Department of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, NigeriaDepartment of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, NigeriaDepartment of Human Physiology, Faculty of Basic Medical Sciences, Delta State University, Abraka, NigeriaDepartment of Nursing and Midwifery, University of Central Lancashire, Preston, EnglandDepartment of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, NigeriaBackground: Diabetes mellitus is a metabolic illness defined by elevated blood sugar levels caused by insulin deficit or resistance, as well as structural and functional problems in several organs. Aim and Objectives: This study assesses the efficacy of Commelina diffusa Extract (CDE) on the reproductive functions of diabetic male Wistar rats. Material and Methods: Thirty mature male Wistar rats were grouped into five groups of five rats each. Group 1: Normal control group; Group 2: High Fat Diet (HFD) + Streptozotocin (STZ); Group 3: HFD + STZ + 300mg/kg CDE; Group 4: HFD + STZ + 600 mg/kg CDE; Group 5: HFD + STZ + 1200 mg/kg CDE. All treatments were carried out for 21 days. On 22nd day of the experiment, after an overnight fast, the experimental rats were sacrificed via cervical dislocation, and the testicular tissues were collected for biochemical, hormonal, and semen quality examination. The study found a substantial drop (p < 0.05) in antioxidant activity, male sex hormones, and sperm quality. Treatment with CDE significantly repaired the damage caused by diabetes. Conclusion: CDE is efficient in reducing oxidative stress, increasing antioxidant defense, improving reproductive hormone balance, and preserving male reproductive health in the face of poor metabolic circumstances.https://www.jkimsu.com/jkimsu-vol14no1/JKIMSU,%20Vol.%2014,%20No.%201,%20January-March%202025%20Page%2040-48.pdftestishypoglycemic agentoxidative stress |
| spellingShingle | Efe Jennifer Jaiyeoba-Ojigho Lilian Ebele Chris-Ozoko Efemena Amarere Ikechukwu Emmanuel Okolie Tejiri Opiri Evaluation of the anti-diabetic effects of Commelina diffusa on testicular tissue of male Wistar rats Journal of Krishna Institute of Medical Sciences University testis hypoglycemic agent oxidative stress |
| title | Evaluation of the anti-diabetic effects of Commelina diffusa on testicular tissue of male Wistar rats |
| title_full | Evaluation of the anti-diabetic effects of Commelina diffusa on testicular tissue of male Wistar rats |
| title_fullStr | Evaluation of the anti-diabetic effects of Commelina diffusa on testicular tissue of male Wistar rats |
| title_full_unstemmed | Evaluation of the anti-diabetic effects of Commelina diffusa on testicular tissue of male Wistar rats |
| title_short | Evaluation of the anti-diabetic effects of Commelina diffusa on testicular tissue of male Wistar rats |
| title_sort | evaluation of the anti diabetic effects of commelina diffusa on testicular tissue of male wistar rats |
| topic | testis hypoglycemic agent oxidative stress |
| url | https://www.jkimsu.com/jkimsu-vol14no1/JKIMSU,%20Vol.%2014,%20No.%201,%20January-March%202025%20Page%2040-48.pdf |
| work_keys_str_mv | AT efejenniferjaiyeobaojigho evaluationoftheantidiabeticeffectsofcommelinadiffusaontesticulartissueofmalewistarrats AT lilianebelechrisozoko evaluationoftheantidiabeticeffectsofcommelinadiffusaontesticulartissueofmalewistarrats AT efemenaamarere evaluationoftheantidiabeticeffectsofcommelinadiffusaontesticulartissueofmalewistarrats AT ikechukwuemmanuelokolie evaluationoftheantidiabeticeffectsofcommelinadiffusaontesticulartissueofmalewistarrats AT tejiriopiri evaluationoftheantidiabeticeffectsofcommelinadiffusaontesticulartissueofmalewistarrats |