Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to progressive cognitive decline and significant disruptions in hippocampal neural networks, critically impacting memory and learning. Understanding the neural mechanisms underlying these impairments is essential for developing effe...

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Bibliographic Details
Main Authors: Alexander Erofeev, Egor Vinokurov, Anastasia Bol’shakova, Ilya Bezprozvanny, Olga Vlasova
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
5xFAD
calcium imaging
miniscope
LFP
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1550673/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1550673/full

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