Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

Multiple gut antimicrobial mechanisms are coordinated in space and time to efficiently fight foodborne pathogens. In Drosophila melanogaster, production of reactive oxygen species (ROS) and antimicrobial peptides (AMPs) together with intestinal cell renewal play a key role in eliminating gut microbe...

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Bibliographic Details
Main Authors: Fatima Tleiss, Martina Montanari, Romane Milleville, Olivier Pierre, Julien Royet, Dani Osman, Armel Gallet, C Leopold Kurz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
bacteria
immunity
pathogens
intestine
duox
trpa1
Online Access:https://elifesciences.org/articles/98716
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https://elifesciences.org/articles/98716

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