Erinacine A-Enriched <i>Hericium erinaceus</i> Mycelium Ethanol Extract Lessens Cellular Damage in Cell and <i>Drosophila</i> Models of Spinocerebellar Ataxia Type 3 by Improvement of Nrf2 Activation

Erinacine A-Enriched <i>Hericium erinaceus</i> Mycelium Ethanol Extract Lessens Cellular Damage in Cell and <i>Drosophila</i> Models of Spinocerebellar Ataxia Type 3 by Improvement of Nrf2 Activation

Spinocerebellar ataxia type 3 (SCA3), caused by the abnormal expansion of polyglutamine (polyQ) in the ataxin-3 protein, is one of the inherited polyQ neurodegenerative diseases that share similar genetic and molecular features. Mutant polyQ-expanded ataxin-3 protein is prone to aggregation in affec...

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Main Authors: Yu-Ling Wu, Hai-Lun Sun, Jui-Chih Chang, Wei-Yong Lin, Pei-Yin Chen, Chin-Chu Chen, Li-Ya Lee, Chien-Chun Li, Mingli Hsieh, Haw-Wen Chen, Ya-Chen Yang, Chin-San Liu, Kai-Li Liu
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antioxidants
Subjects:
autophagy
erinacine A-enriched <i>Hericium erinaceus</i> mycelium
mutant polyQ-expanded ataxin-3
Nrf2
oxidative stress
PolyQ diseases
Online Access:https://www.mdpi.com/2076-3921/13/12/1495
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