Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8+ T cells generating CD4+CD25+ regulatory T cells

Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8+ T cells generating CD4+CD25+ regulatory T cells

Abstract The roles of donor liver natural killer (NK) cells in allogeneic liver transplantation remains controversial. Herein, we investigated the effects of liver NK cells on liver allograft tolerance by using liver NK cells and allogeneic spleen T cell co-culture in vitro experiments and the rat o...

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Bibliographic Details
Main Authors: Jiandong Yu, Jiayan Wu, Tianzhu Long, Lihong Lv, Zhiping Chen, Zeyu Lin, Hongquan Zhu, Guolin Li, Yunle Wan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Liver NK cells
Liver transplantation
Immunoregulation
CD4+CD25+T lymphocytes
Allograft rejection
Online Access:https://doi.org/10.1038/s41598-025-06456-1
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https://doi.org/10.1038/s41598-025-06456-1

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