Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

Abstract Microbial cell factories produce valuable compounds by exploiting cytochrome P450 catalytic systems. However, the inefficient electron transfer flux (ETF) between P450 and cytochrome P450 reductase (CPR) hinders the efficient synthesis of natural products. Herein, an ETF is systematically e...

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Bibliographic Details
Main Authors: Wenzhao Xu, Pengling Wei, Lirong Chen, Ling Gao, Xiaole Xia
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
cytochrome P450 enzymes
electron transfer flux
P450 reductases
RNA‐biosensors
serotonin
tryptamine‐5‐hydroxylases
Online Access:https://doi.org/10.1002/advs.202414859
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https://doi.org/10.1002/advs.202414859

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