Differentiation of Isomeric TAT1-CARNOSINE Peptides by Energy-Resolved Mass Spectrometry and Principal Component Analysis

Differentiation of Isomeric TAT1-CARNOSINE Peptides by Energy-Resolved Mass Spectrometry and Principal Component Analysis

L-carnosine (Car) is an endogenous dipeptide with significant potential in drug discovery for neurodegenerative diseases, while TAT1, a small arginine-rich peptide derived from the HIV-1 trans-activator protein (TAT), is known to stimulate proteasome activity. In this study, three isomeric peptides...

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Bibliographic Details
Main Authors: Alicia Maroto, Olivier Briand, Alessia Distefano, Filiz Arioz, Olivier Monasson, Elisa Peroni, Giuseppe Grasso, Christine Enjalbal, Antony Memboeuf
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
isomeric peptides
carnosine
TAT1
high-resolution mass spectrometry
Principal Component Analysis
MS/MS
Online Access:https://www.mdpi.com/1420-3049/30/4/853
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