Co-morbid mechanisms of intervertebral disc degeneration and osteoporosis: biomechanical coupling and molecular pathways synergistically driving degenerative lesions
Abstract Degenerative orthopedic illnesses, such as osteoporosis (OP) and intervertebral disc degeneration (IVDD), are common in the elderly and are defined by loss of bone mass and degradation of the intervertebral disc matrix, respectively. These conditions cause persistent pain and disability. Al...
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| Main Authors: | Zhifa Ling, Xiaoli Zeng, Qiaoyan Luo, Xue Li, Lijun Cui |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-025-06075-6 |
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