Co-morbid mechanisms of intervertebral disc degeneration and osteoporosis: biomechanical coupling and molecular pathways synergistically driving degenerative lesions

Abstract Degenerative orthopedic illnesses, such as osteoporosis (OP) and intervertebral disc degeneration (IVDD), are common in the elderly and are defined by loss of bone mass and degradation of the intervertebral disc matrix, respectively. These conditions cause persistent pain and disability. Al...

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Bibliographic Details
Main Authors: Zhifa Ling, Xiaoli Zeng, Qiaoyan Luo, Xue Li, Lijun Cui
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-025-06075-6
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