The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation

The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation

IntroductionThe neuroimmune actions of ethanol have recently gained significant attention. Concurrently, the kynurenine pathway, the main catabolic route of tryptophan (TRP), has emerged as a novel target for modulating drug abuse and as a critical immune regulator. This pathway is implicated in beh...

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Main Authors: Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Nuria Morales-Puerto, Rebeca Vidal, Álvaro Del Río-García, Carlos Núñez-de la Calle, Lluna Careaga, María Dolores Gutiérrez-López, Esther O’Shea, María Isabel Colado
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
ethanol
kynurenine
chronic intermittent ethanol (CIE)
immune system
anxiety
memory
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1628527/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1628527/full

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