A neural circuit for sex-dependent conditioned pain hypersensitivity in mice

Abstract The neural mechanisms underlying sex-specific pain, in which males and females exhibit distinct responses to pain, remain poorly understood. Here we show that in a mouse model of male-specific pain hypersensitivity response to pain conditioning environments (contextual pain hypersensitivity...

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Bibliographic Details
Main Authors: Mingjun Zhang, Ziyun Ni, Jun Ma, An Liu, Ying Liu, Qianqian Lou, Wan-Ying Dong, Zhi Zhang, Juan Li, Peng Cao
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58851-x
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