Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits

Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits

Abstract Background Parkinson’s disease is characterized by a progressive loss of dopaminergic neurons in the nigrostriatal pathway, leading to dopamine deficiency and motor impairments. Current treatments, such as L-DOPA, provide symptomatic relief but result in off-target effects and diminished ef...

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Bibliographic Details
Main Authors: Erik H. Douma, Jesse Stoop, Matthijs V. R. Lingl, Marten P. Smidt, Lars P. van der Heide
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Cell & Bioscience
Subjects:
Parkinson’s disease
Dopamine
TH
Ser40
PDE inhibition
GUCY2C
Online Access:https://doi.org/10.1186/s13578-024-01312-7
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https://doi.org/10.1186/s13578-024-01312-7

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