Alterations in the gut microbiome and metabolism profiles reveal the possible molecular mechanism of renal injury induced by hyperuricemia in a mouse model of renal insufficiency

Alterations in the gut microbiome and metabolism profiles reveal the possible molecular mechanism of renal injury induced by hyperuricemia in a mouse model of renal insufficiency

Objectives: To investigate the role of the intestinal flora and metabolites in the development of hyperuricemic renal injury in chronic kidney disease (CKD).Methods: Unilaterally nephrectomized mice were fed with adenine and potassium oxonate for 9 weeks. HE staining combined with plasma biochemical...

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Bibliographic Details
Main Authors: Ping Liu, Jianli Yang, Meiping Jin, Ping Hu, Yifan Zhu, Yuyan Tang, Yu Chen, Xudong Xu, Haidong He
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Chronic kidney disease
hyperuricemia
renal injury
gut microbiota
metabolism profiling
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2387429
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https://www.tandfonline.com/doi/10.1080/0886022X.2024.2387429

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