Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species

Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species

ABSTRACT Bordetella pertussis, which causes the acute human disease whooping cough, evolved from Bordetella bronchiseptica, which causes long-term, chronic infections in a broad range of mammals. Both B. pertussis and B. bronchiseptica produce adenylate cyclase toxin (ACT), a bifunctional protein wi...

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Bibliographic Details
Main Authors: Alexa R. Wolber, Liliana S. McKay, Katlyn B. Mote, Richard M. Johnson, Carol S. Inatsuka, Peggy A. Cotter
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
Bordetella
adenylate cyclase toxin
acylation
bacterial respiratory infection
post-translational modification
Bordetella pertussis
Online Access:https://journals.asm.org/doi/10.1128/mbio.01082-25
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https://journals.asm.org/doi/10.1128/mbio.01082-25

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