Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection

Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection

Abstract Enterococcus faecalis is responsible for numerous serious infections, and treatment options often include ampicillin combined with an aminoglycoside or dual beta-lactam therapy with ampicillin and a third-generation cephalosporin. The mechanism of dual beta-lactam therapy relies on the satu...

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Main Authors: Simone Giuliano, Jacopo Angelini, Floriana Campanile, Paola Conti, Sarah Flammini, Alberto Pagotto, Francesco Sbrana, Luca Martini, Denise D’Elia, Mohd H. Abdul-Aziz, Menino O. Cotta, Jason A. Roberts, Robert A. Bonomo, Carlo Tascini
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Ampicillin
Ceftobiprole
Enterococcus faecalis
Infective endocarditis
Synergism
Therapeutic drug monitoring
Online Access:https://doi.org/10.1038/s41598-025-87512-8
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https://doi.org/10.1038/s41598-025-87512-8

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