Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome

Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome

Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC<sub>12</sub>) that can be chain-shortened four rounds to succinyl-CoA,...

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Bibliographic Details
Main Authors: Yuxun Zhang, Bob B. Zhang, Sivakama S. Bharathi, Joanna Bons, Jacob P. Rose, Samah Shah, Steven F. Dobrowolski, Sunder Sims-Lucas, Birgit Schilling, Eric S. Goetzman
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
peroxisome
sirtuin-5
fatty acid oxidation
Online Access:https://www.mdpi.com/2218-273X/14/12/1508
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