R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial

R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial

IntroductionThe recently licenced R21/Matrix-M vaccine induces a protective antibody response. In this study, we examined vaccine-induced responses in semi-immune adults in a controlled human malaria infection (CHMI) Phase IIb clinical trial.MethodsPlasma and peripheral blood mononuclear cells from...

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Main Authors: Elizabeth Kibwana, Caroline Bundi, Domtila Kimani, Lydia Nyamako, Kelvias Keter, Agnes Mutiso, Rodney Ogwang, Duncan Bellamy, Katerina Rapi, Amelia Bajer, Samuel Provstgaard-Morys, Lisa Stockdale, Olivia Munoz, Mehreen S. Datoo, Alison Lawrie, Fernando Ramos-Lopez, Rachel Roberts, Mainga Hamaluba, Adrian V. S. Hill, Philip Bejon, Katie J. Ewer, Melissa Kapulu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
malaria
R21/Matrix-M
controlled human malaria infection
antibodies
complement fixing antibodies
memory B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1620365/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1620365/full

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