Modulating the platelet-mediated innate foreign body response to affect in situ vascular tissue engineering outcomes

Modulating the platelet-mediated innate foreign body response to affect in situ vascular tissue engineering outcomes

Abstract The success of implanted tissue-engineered vascular grafts (TEVGs) relies on the coordinated inflammation and wound healing processes that simultaneously degrade the scaffold and guide the formation of a neovessel. Dysregulated responses can lead to aberrant remodeling (e.g., stenosis), imp...

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Main Authors: Mackenzie E. Turner, Jingru Che, Joseph T. Leland, Delaney J. Villarreal, Sahana Rajesh, Sugath Suravarapu, Kan N. Hor, Matthew G. Wiet, Bryce A. Kerlin, Tai Yi, Cameron A. Best, James W. Reinhardt, Christopher K. Breuer
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-025-00419-w
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https://doi.org/10.1038/s41536-025-00419-w

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