Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer

Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer

Purpose: To understand the broader genetic landscape of male breast cancer (MBC), focusing on the utility of genome sequencing (GS) beyond BRCA1/2 (HGNC: 1100, 1101) variants. Methods: Twenty-four patients with MBC underwent a multistep genetic analysis. Initial screening targeted BRCA1/2 variants f...

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Main Authors: Wen Wen, Sen Zhao, Yiwen Jiang, Chengzhu Ou, Changyuan Guo, Ziqi Jia, Jiayi Li, Yansong Huang, Hengyi Xu, Pengming Pu, Tongxuan Shang, Lin Cong, Xiang Wang, Nan Wu, Jiaqi Liu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Genetics in Medicine Open
Subjects:
Genetic testing
Genome sequencing
Male breast cancer
Mutational landscape
Polygenic risk score
Online Access:http://www.sciencedirect.com/science/article/pii/S2949774424010458
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