A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease

A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease

Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. However, current treatments only manage symptoms and lack the ability to slow or prevent disease progression. We utilized a systems genetics approach to identify potential risk genes and repurposable drugs for...

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Bibliographic Details
Main Authors: Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00870-y
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