Derivation of a comprehensive semi-empirical proton RBE model from published experimental cell survival data collected in the PIDE database

Derivation of a comprehensive semi-empirical proton RBE model from published experimental cell survival data collected in the PIDE database

We aimed to develop a comprehensive proton relative biological effectiveness (RBE) model based on accumulated cell survival data in the literature. Our approach includes four major components: (1) Eligible cell survival data with various linear energy transfers (LETs) in the Particle Irradiation Dat...

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Bibliographic Details
Main Authors: Jian-Yue Jin, Jiankui Yuan, Xiaohang Qin, Yinghui Li, Huagang Yan, Nancy L. Oleinick, Min Yao, Quintin Pan, Feng-Ming (Spring) Kong, Mitchell Machtay
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Oncology
Subjects:
relative biological effectiveness (RBE)
proton therapy
linear energy transfer (LET)
multiple curve fitting (MCF)
cell survival model
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1415213/full
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https://www.frontiersin.org/articles/10.3389/fonc.2024.1415213/full

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