Fluconazole Dosing for the Prevention of <i>Candida</i> spp. Infections in Hemato-Oncologic Pediatric Patients: Population Pharmacokinetic Modeling and Probability of Target Attainment Simulations

Fluconazole Dosing for the Prevention of <i>Candida</i> spp. Infections in Hemato-Oncologic Pediatric Patients: Population Pharmacokinetic Modeling and Probability of Target Attainment Simulations

<b>Objectives</b>: A population pharmacokinetic (popPK) model was used to evaluate fluconazole dosing regimens for <i>Candida</i> spp. prophylaxis in hemato-oncologic pediatric patients. <b>Methods</b>: Data were collected from patients receiving 3–12 mg/kg of flu...

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Main Authors: Arkadiusz Adamiszak, Katarzyna Derwich, Alicja Bartkowska-Śniatkowska, Krzysztof Pietrzkiewicz, Izabela Niewiadomska-Wojnałowicz, Andrzej Czyrski, William J. Jusko, Agnieszka Bienert
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
fluconazole
population pharmacokinetics
Monte Carlo simulations
probability of target attainment
<i>Candida</i> spp. prophylaxis
Online Access:https://www.mdpi.com/1999-4923/17/4/488
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