Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

Objectives Recent investigations in humans and mouse models with lupus have revealed evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen species (mROS) in T cells and neutrophils. This can provoke numerous cellular changes including oxidation of nucleic acids, prote...

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Main Authors: Mariana J Kaplan, Karen A Fortner, Luz P Blanco, Iwona Buskiewicz, Nick Huang, Pamela C Gibson, Deborah L Cook, Hege L Pedersen, Peter S T Yuen, Michael P Murphy, Ralph C Budd, ANDRAS PERL
Format: Article
Language:English
Published: BMJ Publishing Group 2020-10-01
Series:Lupus Science and Medicine
Online Access:https://lupus.bmj.com/content/7/1/e000387.full
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https://lupus.bmj.com/content/7/1/e000387.full

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