A comprehensive evaluation of diversity measures for TCR repertoire profiling

A comprehensive evaluation of diversity measures for TCR repertoire profiling

Abstract Background T cells play a crucial role in adaptive immunity, as they monitor internal and external immunogenic signals through their specific receptors (TCRs). Using high-throughput sequencing, one can assess TCR repertoire in various clinical settings and describe it quantitatively by calc...

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Bibliographic Details
Main Authors: Justyna Mika, Alicja Polanska, Kim RM Blenman, Lajos Pusztai, Joanna Polanska, Serge Candéias, Michal Marczyk
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Biology
Subjects:
TCR profiling
Diversity
Richness
Evenness
TCR sequencing
Immunosequencing
Online Access:https://doi.org/10.1186/s12915-025-02236-5
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https://doi.org/10.1186/s12915-025-02236-5

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