Increasing robustness of in vitro assay for immnosuppressive effect of mesenchymal stromal/stem cells: The role of inflammatory cytokine production by peripheral blood mononuclear cells

Increasing robustness of in vitro assay for immnosuppressive effect of mesenchymal stromal/stem cells: The role of inflammatory cytokine production by peripheral blood mononuclear cells

Introduction: The Quality by Design (QbD) approach for developing cell therapy products using mesenchymal stromal/stem cells (MSCs) is a promising method for designing manufacturing processes to improve the quality of MSC products. It is crucial to ensure the reproducibility and robustness of the te...

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Bibliographic Details
Main Authors: Rumi Sawada, Shinji Kusakawa, Mika Kusuhara, Kazusa Tanaka, Takumi Miura, Satoshi Yasuda, Yoji Sato
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Regenerative Therapy
Subjects:
MLR assay
MSC
PBMC proliferation
Inflammatory cytokines
CQA
QbD
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320424002360
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