Synthesis of 3-Carboxy-6-sulfamoylquinolones and Mefloquine-Based Compounds as Panx1 Blockers: Molecular Docking, Electrophysiological and Cell Culture Studies

Synthesis of 3-Carboxy-6-sulfamoylquinolones and Mefloquine-Based Compounds as Panx1 Blockers: Molecular Docking, Electrophysiological and Cell Culture Studies

The membrane channel protein Panx1 is a promising therapeutic target since its involvement was demonstrated in a variety of pathologies such as neuropathic pain, ischemic stroke and cancer. As a continuation of our previous work in this field, we report here the synthesis and biological evaluation o...

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Bibliographic Details
Main Authors: Letizia Crocetti, Maria Paola Giovannoni, Tengis S. Pavlov, Veniamin Ivanov, Fabrizio Melani, Gabriella Guerrini
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
Panx1
channel blockers
quinolones
patch clamp
molecular docking
multiple linear regression (MLR)
Online Access:https://www.mdpi.com/1420-3049/30/10/2171
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