Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239

Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239

<b>Background:</b> Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tum...

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Bibliographic Details
Main Authors: Claire Louise Kelly, Martyna Wydrzynska, Marie M. Phelan, Sofya Osharovich, Edward J. Delikatny, Violaine Sée, Harish Poptani
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Metabolites
Subjects:
glioblastoma
metabolomics
metabolism
hypoxia
3D spheroids
cell cycle
Online Access:https://www.mdpi.com/2218-1989/15/2/76
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