Network pharmacology and metabolomics reveal mathurameha, a Thai traditional Anti-Diabetic formula, enhances glucose metabolism through PI3K-AKT/AMPK/GLUT4 pathway modulation

Network pharmacology and metabolomics reveal mathurameha, a Thai traditional Anti-Diabetic formula, enhances glucose metabolism through PI3K-AKT/AMPK/GLUT4 pathway modulation

Abstract Traditional herbal formulations offer promising avenues for diabetes management by targeting multiple molecular pathways. Mathurameha (MT), a polyherbal preparation, has been historically used for its antidiabetic potential. However, its molecular mechanisms remain largely unexplored. FrE e...

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Main Authors: Subhadip Banerjee, Wuttichai Jaidee, Narawadee Rujanapun, Thidarat Duangyod, Tharakorn Maneerat, Pravaree Phuneerub, Kulwadee Malee, Siam Popluechai, Virayu Suthiphasilp, Panupong Puttarak, Poonsit Hiransai, Surat Laphookhieo, Salfarina Ramli, Wim Vanden Berghe, Geoffrey A. Cordell, Rawiwan Charoensup
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Mathurameha
Thai traditional medicine
Twenty-six medicinal plant mixture
Antidiabetic activity
Glucose transport
LC-MS/MS-QTOF analysis
Online Access:https://doi.org/10.1038/s41598-025-15556-x
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https://doi.org/10.1038/s41598-025-15556-x

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