Human type I interferons protect Vero E6 and ARPE-19 cells against West Nile virus and are neutralized by pathogenic autoantibodies

Human type I interferons protect Vero E6 and ARPE-19 cells against West Nile virus and are neutralized by pathogenic autoantibodies

Abstract Auto-antibodies (auto-Abs) that neutralize type I interferons (IFNs) have been implicated in severe viral infections, including ~ 40% of cases of West Nile virus (WNV) neuroinvasive disease (WNND). Developing robust in vitro models to evaluate the protective effects of type I IFNs against v...

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Main Authors: Alessandro Ferrari, Irene Cassaniti, Francesca Rovida, Daniele Lilleri, Stefania Croce, Francesca Trespidi, Stefano Ghirardello, Adrian Gervais, Shen-Ying Zhang, Jean-Laurent Casanova, Alessandro Borghesi, Fausto Baldanti
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
WNV
Type I IFNs
Auto-antibody
Immunity
Neutralizing antibody
Online Access:https://doi.org/10.1038/s41598-025-89312-6
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https://doi.org/10.1038/s41598-025-89312-6

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