Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer

Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer

Abstract Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) is an aggressive disease with limited predictive biomarkers, often leading to ineffective treatments and unnecessary toxicity. Circulating tumor DNA (ctDNA) provides a promising real-time, non-invasive tool for monitorin...

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Main Authors: Daniel A. Ruiz-Torres, Ross D. Merkin, Michael E. Bryan, Julia Mendel, Vasileios Efthymiou, Thomas Roberts, Manisha J. Patel, Jong C. Park, Amber Chevalier, Clodagh Murray, Lisa Gates, Christodoulos Pipinikas, Shannon L. Stott, Adam S. Fisch, Lori J. Wirth, Daniel L. Faden
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01084-4
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https://doi.org/10.1038/s41698-025-01084-4

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