Degradation kinetics of Andrographolide in aqueous solution, product identification and biological activity evaluation

Degradation kinetics of Andrographolide in aqueous solution, product identification and biological activity evaluation

Abstract Andrographolide (1) is a labdane-type diterpene lactone and the major bioactive metabolite (2.39%) in the leaves of Andrographis paniculata (Acanthaceae). To further explore its stability, the thermal degradation kinetics of compound 1 at pH 2.0, pH 6.0, and pH 8.0 were modeled at three tem...

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Main Authors: Wuttichai Jaidee, Narawadee Rujanapun, Kulawadee Malee, Suchada Chaisawadi, Panupong Puttarak, Poonsit Hiransai, Geoffrey A. Cordell, Satyajit D. Sarker, Lutfun Nahar, Rawiwan Charoensup
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Andrographolide
Degradation
pH dependency
Product characterization
Arrhenius equation
NO production
Online Access:https://doi.org/10.1038/s41598-025-13652-6
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https://doi.org/10.1038/s41598-025-13652-6

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