Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels
Introduction. Gum Arabic (GA) is a complex polysaccharide with proven prebiotic properties and potentially beneficial systemic effects. Methods. We randomly allocated 36 chronic kidney disease (CKD) patients to receive 10, 20, or 40 grams daily of GA for four weeks and studied the systemic effects o...
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| Format: | Article |
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2017-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2017/9501470 |
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| author | Sarra Elamin Mariam J. Alkhawaja Amina Y. Bukhamsin Mohamed A. S. Idris Muntasir M. Abdelrahman Nasrulla K. Abutaleb Abdulrahman A. Housawi |
| author_facet | Sarra Elamin Mariam J. Alkhawaja Amina Y. Bukhamsin Mohamed A. S. Idris Muntasir M. Abdelrahman Nasrulla K. Abutaleb Abdulrahman A. Housawi |
| author_sort | Sarra Elamin |
| collection | DOAJ |
| description | Introduction. Gum Arabic (GA) is a complex polysaccharide with proven prebiotic properties and potentially beneficial systemic effects. Methods. We randomly allocated 36 chronic kidney disease (CKD) patients to receive 10, 20, or 40 grams daily of GA for four weeks and studied the systemic effects of this intervention. Results. Thirty participants completed the study with baseline glomerular filtration rate 29.1±9.9 mL/min/1.7 m2. In contrast to previous observations, we found no effect on serum urea or creatinine levels. GA supplementation was associated with a small but statistically significant drop in serum sodium level (138±2 to 136±3 mmol/L, p = 0.002) without affecting other electrolytes, urine volume, or indoxyl sulfate (IS) levels. GA supplementation was also associated with a significant drop in C-reactive protein (CRP) level (3.5±1.5 to 2.8±1.6 ng/mL, p = 0.02) even in patients who received only 10 g/day (4.4±1.2 to 3.2±1.5 ng/mL, p = 0.03). Conclusions. Supplementing the diet of CKD patients with 10–40 g/day of GA significantly reduced CRP level which could have a positive impact on these patients’ morbidity and mortality. This trial is registered with Saudi Clinical Trial Registry number 15011402. |
| format | Article |
| id | doaj-art-342c8aa01ab14fd987c4ef141df76370 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-342c8aa01ab14fd987c4ef141df763702025-02-03T01:12:21ZengWileyInternational Journal of Nephrology2090-214X2090-21582017-01-01201710.1155/2017/95014709501470Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate LevelsSarra Elamin0Mariam J. Alkhawaja1Amina Y. Bukhamsin2Mohamed A. S. Idris3Muntasir M. Abdelrahman4Nasrulla K. Abutaleb5Abdulrahman A. Housawi6King Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaKing Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaKing Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaKing Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaKing Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaKing Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaKing Fahad Specialist Hospital, Dammam 31444, Saudi ArabiaIntroduction. Gum Arabic (GA) is a complex polysaccharide with proven prebiotic properties and potentially beneficial systemic effects. Methods. We randomly allocated 36 chronic kidney disease (CKD) patients to receive 10, 20, or 40 grams daily of GA for four weeks and studied the systemic effects of this intervention. Results. Thirty participants completed the study with baseline glomerular filtration rate 29.1±9.9 mL/min/1.7 m2. In contrast to previous observations, we found no effect on serum urea or creatinine levels. GA supplementation was associated with a small but statistically significant drop in serum sodium level (138±2 to 136±3 mmol/L, p = 0.002) without affecting other electrolytes, urine volume, or indoxyl sulfate (IS) levels. GA supplementation was also associated with a significant drop in C-reactive protein (CRP) level (3.5±1.5 to 2.8±1.6 ng/mL, p = 0.02) even in patients who received only 10 g/day (4.4±1.2 to 3.2±1.5 ng/mL, p = 0.03). Conclusions. Supplementing the diet of CKD patients with 10–40 g/day of GA significantly reduced CRP level which could have a positive impact on these patients’ morbidity and mortality. This trial is registered with Saudi Clinical Trial Registry number 15011402.http://dx.doi.org/10.1155/2017/9501470 |
| spellingShingle | Sarra Elamin Mariam J. Alkhawaja Amina Y. Bukhamsin Mohamed A. S. Idris Muntasir M. Abdelrahman Nasrulla K. Abutaleb Abdulrahman A. Housawi Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels International Journal of Nephrology |
| title | Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels |
| title_full | Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels |
| title_fullStr | Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels |
| title_full_unstemmed | Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels |
| title_short | Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels |
| title_sort | gum arabic reduces c reactive protein in chronic kidney disease patients without affecting urea or indoxyl sulfate levels |
| url | http://dx.doi.org/10.1155/2017/9501470 |
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