Structure-activity study of oncocins modified with cationic polar moieties at the termini

Structure-activity study of oncocins modified with cationic polar moieties at the termini

The critical emergence of antimicrobial resistance is aggravated by a pipeline deficient in novel antibiotic classes against Gram-negative pathogens. Proline-rich antimicrobial peptides (PrAMPs) are attractive starting points for novel antibiotics, capable of targeting Gram-negative pathogens. Here,...

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Main Authors: Johan Storm Jørgensen, Anita Wester, Carina Sofia Silva Matias, Lina Maria Cavaco, Carina Vingsbo Lundberg, Camilla Brolin, Elnaz Harifi Mood, Dorota Żabicka, Magdalena Tomczak, Malgorzata Urbas, Fredrik Björkling, Peter E. Nielsen, Henrik Franzyk
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Oncocin analogs
Bacteria-penetrating moiety
Cationic modification
Structure-activity relationships
Antibacterial activity
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417425000408
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