Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer’s Disease

Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer’s Disease

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by extracellular amyloid plaques, predominantly consisting of amyloid-<i>β</i> (A<i>β</i>) peptides. The oligomeric form of A<i>β</i> is acknowledged as the most neurotoxic, propelling...

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Bibliographic Details
Main Authors: Marilena K. Theodoropoulou, Konstantina D. Vraila, Nikos C. Papandreou, Georgia I. Nasi, Vassiliki A. Iconomidou
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
Alzheimer’s disease
Cathepsin B
aggregation-prone regions
amyloid-<i>β</i>
A<i>β</i>
molecular dynamics
Online Access:https://www.mdpi.com/2218-273X/15/1/28
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