Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy

Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy

Abstract Non-small cell lung cancer (NSCLC) represents the most prevalent form of lung cancer, exerting a substantial impact on global health. Cisplatin-based chemotherapy is the standard treatment for NSCLC, but resistance and severe side effects present significant clinical challenges. Recently, n...

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Main Authors: Man Fang, Lei Cao, Zhao Zhang, Zhen Yu, Yue Shen, Jieqi Chen, Juan Chen, Yue-Qin Li, Zhaoqian Liu, Yingcai Meng, Haihua Xiao, Qiang Qu, Ji-Ye Yin, Xiang-Ping Li
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
NSCLC
Novel tetravalent platinum
Albumin
Ammonium Tetrathiomolybdate
Tumor chemo-immunotherapy
Online Access:https://doi.org/10.1186/s12951-025-03310-4
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https://doi.org/10.1186/s12951-025-03310-4

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