Hippocampal volumes in UK Biobank are associated with APOE only in older adults

Hippocampal volumes in UK Biobank are associated with APOE only in older adults

Abstract INTRODUCTION The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E (APOE) genotype on total hippocampal volume. METHODS Using neuroimaging data from 37,463 UK Bi...

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Bibliographic Details
Main Authors: Ariya Chaloemtoem, Vera Thornton, Yoonhoo Chang, Andrey P. Anokhin, Michaël E. Belloy, Janine Bijsterbosch, Brian A. Gordon, Sarah M. Hartz, Laura J. Bierut
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
age
Alzheimer's disease
apolipoprotein E
hippocampus
neurodegeneration
UK Biobank
Online Access:https://doi.org/10.1002/dad2.70024
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