Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression

Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression

Abstract Osteoarthritis is a common degenerative joint disease, in which mechanical overloading disrupts subchondral bone remodeling before cartilage degeneration and the osteocytes in the subchondral bone are mainly responsible for mechanosensing. However, their functional role in the early osteoar...

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Main Authors: Na Liu, Yuze Ma, Wang Gong, Xiaoyan Shao, Tianshu Shi, Lan Li, Wenshu Wu, Xiang Chen, Yong Shi, Pan Zhang, Jiaquan Lin, Chengzhi Wang, Depeng Fang, Lin Yang, Pu Wang, Wentian Gao, Yi He, Xueying An, Rui Du, Ying Chen, Bin Liu, Jianghui Qin, Dongyang Chen, Pingqiang Cai, Qing Jiang, Baosheng Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59861-5
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https://doi.org/10.1038/s41467-025-59861-5

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