Variants in the β-globin locus are associated with pneumonia in African American children

Variants in the β-globin locus are associated with pneumonia in African American children

Summary: In African American adults, the strongest genetic predictor of pneumonia appears to be the A allele of rs334, a variant in the β-globin gene, which in homozygous form causes sickle cell disease (SCD). No comparable studies have been done in African American children. We performed genome-wid...

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Bibliographic Details
Main Authors: Nadine L.N. Halligan, Sarah C. Hanks, Karen Matsuo, Taylor Martins, Sebastian Zöllner, Michael W. Quasney, Laura J. Scott, Mary K. Dahmer
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:HGG Advances
Subjects:
children
African American
sickle cell
pneumonia
GWAS
hemoglobin
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247724001143
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http://www.sciencedirect.com/science/article/pii/S2666247724001143

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