Damaging effect of ischemia on the development of retinal organoids derived from human embryonic stem cells

Damaging effect of ischemia on the development of retinal organoids derived from human embryonic stem cells

AIM: To explore the changes in early retinal development after the occurrence of ischemia. METHODS: Human retinal organoids (hROs) of day 18 or day 30 were treated with oxygen-glucose deprivation and reperfusion (OGD/R) to simulate the retinal ischemia. All hROs were maintained normally until day 60...

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Main Authors: Yu-Han Yan, Hong-Yu Li, Li-Xiong Gao, Wen Li, Ling-Ping Zhao, Quan Zeng, Yu Luo, Tian-Tian Cui, Ru-Ge Zang, Zi Ye, Jia-Fei Xi, Wen Yue, Zhao-Hui Li
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2025-08-01
Series:International Journal of Ophthalmology
Subjects:
retinal diseases
fetal ischemia
oxygen-glucose deprivation and reperfusion
human retinal organoids
retinal ganglion cells
Online Access:http://ies.ijo.cn/en_publish/2025/8/20250803.pdf
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http://ies.ijo.cn/en_publish/2025/8/20250803.pdf

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