A Novel Engineering Cell Therapy Platform Mimicking the Immune Thrombocytopenia‐Derived Platelets to Inhibit Cytokine Storm in Hemophagocytic Lymphohistiocytosis

A Novel Engineering Cell Therapy Platform Mimicking the Immune Thrombocytopenia‐Derived Platelets to Inhibit Cytokine Storm in Hemophagocytic Lymphohistiocytosis

Abstract Hemophagocytic lymphohistiocytosis (HLH) is a common and highly fatal hyperinflammatory syndrome characterized by the aberrant activation of macrophages. To date, there is a lack of targeted therapies for HLH. It is validated that macrophages in HLH efficiently phagocytose anti‐CD41‐platele...

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Bibliographic Details
Main Authors: Zhenyu Liu, Ying Du, Tong Zhou, Ting Qin, Yining Yuan, Weilu Xu, MengKun Fang, Xuemei Wang, Bing Chen, Peipei Xu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
cytokine storm
etoposide
hemophagocytic lymphohistiocytosis
living therapeutics platform
platelets
Online Access:https://doi.org/10.1002/advs.202404571
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https://doi.org/10.1002/advs.202404571

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