Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2

Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2

Abstract Class 3 semaphorins are axon guidance factors implicated in tumor and vascular biology, including invasive activity. Recent studies indicate that semaphorin 3F (SEMA3F) is a potent inhibitor of metastasis; however, its functional role in breast cancer is not fully understood. We found that...

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Main Authors: Hironao Nakayama, Akari Murakami, Hisayo Nishida-Fukuda, Shinji Fukuda, Erina Matsugi, Masako Nakahara, Chiaki Kusumoto, Yoshiaki Kamei, Shigeki Higashiyama
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Breast cancer
Semaphorin 3F
Neuropilin-2
Metastasis
Online Access:https://doi.org/10.1038/s41598-025-91559-y
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https://doi.org/10.1038/s41598-025-91559-y

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