Evolutionary dynamics of recurrent hepatocellular carcinoma under divergent immune selection pressures

Evolutionary dynamics of recurrent hepatocellular carcinoma under divergent immune selection pressures

Hepatocellular carcinoma (HCC) is a highly lethal, aggressive malignancy. Little is known about the evolutionary trajectories of HCC and how clinical decision-making could be informed based on biopsies of the initial tumour. Here, we report the whole-exome sequencing of a unique series of resected H...

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Main Authors: Ankur Chakravarthy, Elisa Pasini, Xun Zhao, Jeffrey To, Shu Yi (Roxana) Shen, Sandra Fischer, Anand Ghanekar, Arndt Vogel, Robert C. Grant, Jennifer Knox, Gonzalo Sapisochin, Gregory J. Gores, Daniel De Carvalho, Mamatha Bhat
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
tumour evolution
immune selection
immune evasion
whole-exome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1537087/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1537087/full

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