Use of gonadotropin-releasing hormone agonists in transgender and gender diverse youth: a systematic review

Use of gonadotropin-releasing hormone agonists in transgender and gender diverse youth: a systematic review

IntroductionPuberty suppression using gonadotropin-releasing hormone agonists (GnRHa) is a reversible medical intervention that halts endogenous puberty, allowing transgender and gender-diverse (TGD) adolescents to avoid the development of secondary sexual characteristics that may cause psychologica...

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Main Authors: Gianluca Tornese, Raffaella Di Mase, Jessica Munarin, Silvia Ciancia, Fabiana Santamaria, Daniela Fava, Egidio Candela, Donatella Capalbo, Carla Ungaro, Nicola Improda, Pierluigi Diana, Patrizia Matarazzo, Laura Guazzarotti, Tommaso Toschetti, Vanessa Sambati, Gianluca Tamaro, Giulia Bresciani, Maria Rosaria Licenziati, Maria Elisabeth Street, Tommaso Aversa, Maurizio Delvecchio, Maria Felicia Faienza, Lorenzo Iughetti, Valeria Calcaterra, Luisa de Sanctis, Mariacarolina Salerno, Roberto Franceschi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Endocrinology
Subjects:
gender dysphoria (GD)
gender incongruence
adolescence
GnRH analog (GnRHa)
LHRH analog
transgender and gender diverse (TGD)
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1555186/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1555186/full

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