Deciphering the role of cuproptosis in the development of intimal hyperplasia in rat carotid arteries using single cell analysis and machine learning techniques

Deciphering the role of cuproptosis in the development of intimal hyperplasia in rat carotid arteries using single cell analysis and machine learning techniques

Abstract This study aims to explore the regulatory role of cuproptosis in carotid intimal hyperplasia (IH), providing new insights into its pathophysiological mechanisms and potential diagnostic and therapeutic strategies. Methods: We downloaded single-cell sequencing and bulk transcriptome data fro...

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Bibliographic Details
Main Authors: Miao He, Hui Chen, Zhengli Liu, Boxiang Zhao, Xu He, Qiujin Mao, Jianping Gu, Jie Kong
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Cuproptosis
Neointimal hyperplasia
Single-cell analysis
Carotid balloon strains
Machine-learning
Online Access:https://doi.org/10.1038/s41598-025-89414-1
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https://doi.org/10.1038/s41598-025-89414-1

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