DNA methylome biomarkers of rheumatoid arthritis-associated interstitial lung disease reflecting lung fibrosis pathways, an exploratory case–control study

DNA methylome biomarkers of rheumatoid arthritis-associated interstitial lung disease reflecting lung fibrosis pathways, an exploratory case–control study

Abstract Rheumatoid Arthritis-associated Interstitial Lung Disease (RA-ILD) significantly reduces life quality and survival, necessitating improvements in its understanding and clinical management. We addressed these goals using DNA methylation analysis, which has not been done in RA-ILD samples, by...

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Main Authors: Bartosz Kaczmarczyk, Carlos de la Calle-Fabregat, Adrian Conde, Ana Catarina Duarte, Natalia Mena-Vazquez, Antonio Fernandez-Nebro, Ana Triguero-Martinez, Santos Castañeda, Raquel Dos-Santos Sobrin, Antonio Mera-Varela, Chary Lopez-Pedrera, Alejandro Escudero-Contreras, Paloma Vela-Casasempere, Maria Molina, Javier Narvaez, Miriam Retuerto-Guerrero, Jose L. Pablos, Juan C. Sarmiento-Monroy, Raimon Sanmarti, Luis Gomez-Carrera, Gema Bonilla, Sara Remuzgo-Martinez, Miguel Angel Gonzalez-Gay, Virginia Leiro-Fernandez, Nair Perez-Gomez, Cristina Vadillo-Font, Lydia Abasolo, Ivette Casafont-Sole, Lourdes Mateo-Soria, Ana Cristina Castillo-Gonzalez, Carlos Marras, Eva Perez-Pampin, Esteban Ballestar, Antonio Gonzalez, On behalf of the MARILD network
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Rheumatoid arthritis
Interstitial lung disease
Biomarkers
Lung fibrosis
DNA methylation
Epigenetics
Online Access:https://doi.org/10.1038/s41598-025-99755-6
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https://doi.org/10.1038/s41598-025-99755-6

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