Genetic insights into causal effects of lipids and lipid-modifying targets on calcific aortic valve stenosis: a Mendelian randomized study

Genetic insights into causal effects of lipids and lipid-modifying targets on calcific aortic valve stenosis: a Mendelian randomized study

Abstract Calcific aortic valve stenosis (CAVS) is steadily rising worldwide with no effective pharmacological agents available. Observational studies implicated dyslipidaemia as a risk factor for CAVS. Whether dyslipidaemia is causative for CAVS and the therapeutic potential of different lipid-modif...

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Bibliographic Details
Main Authors: Chengrong Wu, Qian Pu, Yalin Zou, Juan Jin, Yu Lei, Yaxin Hu, Zhuo Chen, Lei Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Lipids profile
Calcific aortic valve stenosis
Mendelian randomization
PCSK9
pQTL
eQTL
Online Access:https://doi.org/10.1038/s41598-025-15525-4
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https://doi.org/10.1038/s41598-025-15525-4

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