Proteomic characterization of MET-amplified esophageal adenocarcinomas reveals enrichment of alternative splicing- and androgen signaling-related proteins

Proteomic characterization of MET-amplified esophageal adenocarcinomas reveals enrichment of alternative splicing- and androgen signaling-related proteins

Abstract Background Esophageal adenocarcinomas (EACs) represent an evolving tumor entity with high mortality rates. MET amplification is a recurrent driver in EACs and is associated with decreased patient survival. However, the response to MET inhibitors is limited. Recent studies have identified se...

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Bibliographic Details
Main Authors: Bastian Grothey, Su Ir Lyu, Alexander Quaas, Adrian Georg Simon, Jin-On Jung, Wolfgang Schröder, Christiane J. Bruns, Lars M. Schiffmann, Felix C. Popp, Thomas Schmidt, Karl Knipper
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Cellular and Molecular Life Sciences
Subjects:
Oncology
Esophageal adenocarcinomas
MET signaling pathway
Proteomics
Tumor microenvironment
Online Access:https://doi.org/10.1007/s00018-025-05635-7
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https://doi.org/10.1007/s00018-025-05635-7

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