Associations between exposure to volatile organic compounds with obesity in adults
Objective: This study was to investigate the correlation between urine volatile organic compound (VOC) metabolites and obesity-related outcomes, including BMI, waist circumference, obesity, and abdominal obesity. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) conduc...
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Elsevier
2025-03-01
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| Series: | Human Nutrition & Metabolism |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149724000586 |
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| author | Runmiao Wu Lei Jia Xu Zhu Gongchang Guan Junkui Wang Rutai Hui Meijuan Ma Zhao Zhao Hui Pang Ling Zhu |
| author_facet | Runmiao Wu Lei Jia Xu Zhu Gongchang Guan Junkui Wang Rutai Hui Meijuan Ma Zhao Zhao Hui Pang Ling Zhu |
| author_sort | Runmiao Wu |
| collection | DOAJ |
| description | Objective: This study was to investigate the correlation between urine volatile organic compound (VOC) metabolites and obesity-related outcomes, including BMI, waist circumference, obesity, and abdominal obesity. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2016 were utilized for this analysis. Linear regression and logistic regression models were employed to estimate β-coefficients or odds ratios (ORs) along with their corresponding 95 % confidence intervals (CIs). Quantile g-computation (Qgcomp) regression, a method designed to evaluate the combined effects of multiple correlated chemical exposures, was used to assess the mixed influence of VOC metabolites on obesity-related outcomes. Results: A total of 4950 adults were included in this analysis. The median age of the participants was 47 (33, 60) years, with 49.3 % being male. The median BMI was 27.7 (24.2, 32.4) kg/m2, and the median waist circumference was 98.0 (87.3, 109.0) cm. The prevalence of obesity and abdominal obesity was 36.8 % and 56.5 %, respectively. After adjusting for all covariates, urine VOC metabolites (including AAMA, AMCC, BMA, CYMA, DHBMA, 3HPMA, 2HPMA, MA, 2MHA, 3MHA+4MHA, MHBMA3, PGA, and HPMMA) exhibited a negative association with obesity. With the exception of BMA and DHBMA, similar results were observed regarding the association between urine VOC metabolites and the prevalence of abdominal obesity. Additionally, Qgcomp regression analysis revealed a significant negative correlation between the mixture of urine VOC metabolites and all obesity-related outcomes, with 2HPMA demonstrating the strongest influence on this negative association. Conclusion: Our findings suggest a negative relationship between exposure to VOCs, as measured by urine VOC metabolite levels, and obesity in adults. |
| format | Article |
| id | doaj-art-332fec53162f4493a2e40f7a74b49c57 |
| institution | Kabale University |
| issn | 2666-1497 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj-art-332fec53162f4493a2e40f7a74b49c572025-02-06T05:12:47ZengElsevierHuman Nutrition & Metabolism2666-14972025-03-0139200296Associations between exposure to volatile organic compounds with obesity in adultsRunmiao Wu0Lei Jia1Xu Zhu2Gongchang Guan3Junkui Wang4Rutai Hui5Meijuan Ma6Zhao Zhao7Hui Pang8Ling Zhu9Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710000, ChinaDepartment of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, ChinaDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710000, ChinaDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710000, ChinaDepartment of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, ChinaDepartment of Cadre Physical Examination Center, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710000, China; Corresponding author.Department of Cardiology, Xi'an No.9 Hospital, Xi’an, Shaanxi, 710000, China; Corresponding author. Department of Cardiology, Xi'an No.9 Hospital, Xi'an, Shaanxi, 710000, China.Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China; Corresponding author. Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China.Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710000, China; Department of Cardiology, The Third Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, China; Corresponding authors. Department of Cardiology Shaanxi Provincial People's Hospital, 256 youyi West Road, Xi'an, Shaanxi, 710000, China.Objective: This study was to investigate the correlation between urine volatile organic compound (VOC) metabolites and obesity-related outcomes, including BMI, waist circumference, obesity, and abdominal obesity. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2016 were utilized for this analysis. Linear regression and logistic regression models were employed to estimate β-coefficients or odds ratios (ORs) along with their corresponding 95 % confidence intervals (CIs). Quantile g-computation (Qgcomp) regression, a method designed to evaluate the combined effects of multiple correlated chemical exposures, was used to assess the mixed influence of VOC metabolites on obesity-related outcomes. Results: A total of 4950 adults were included in this analysis. The median age of the participants was 47 (33, 60) years, with 49.3 % being male. The median BMI was 27.7 (24.2, 32.4) kg/m2, and the median waist circumference was 98.0 (87.3, 109.0) cm. The prevalence of obesity and abdominal obesity was 36.8 % and 56.5 %, respectively. After adjusting for all covariates, urine VOC metabolites (including AAMA, AMCC, BMA, CYMA, DHBMA, 3HPMA, 2HPMA, MA, 2MHA, 3MHA+4MHA, MHBMA3, PGA, and HPMMA) exhibited a negative association with obesity. With the exception of BMA and DHBMA, similar results were observed regarding the association between urine VOC metabolites and the prevalence of abdominal obesity. Additionally, Qgcomp regression analysis revealed a significant negative correlation between the mixture of urine VOC metabolites and all obesity-related outcomes, with 2HPMA demonstrating the strongest influence on this negative association. Conclusion: Our findings suggest a negative relationship between exposure to VOCs, as measured by urine VOC metabolite levels, and obesity in adults.http://www.sciencedirect.com/science/article/pii/S2666149724000586VOCsObesityNHANESQgcomp |
| spellingShingle | Runmiao Wu Lei Jia Xu Zhu Gongchang Guan Junkui Wang Rutai Hui Meijuan Ma Zhao Zhao Hui Pang Ling Zhu Associations between exposure to volatile organic compounds with obesity in adults Human Nutrition & Metabolism VOCs Obesity NHANES Qgcomp |
| title | Associations between exposure to volatile organic compounds with obesity in adults |
| title_full | Associations between exposure to volatile organic compounds with obesity in adults |
| title_fullStr | Associations between exposure to volatile organic compounds with obesity in adults |
| title_full_unstemmed | Associations between exposure to volatile organic compounds with obesity in adults |
| title_short | Associations between exposure to volatile organic compounds with obesity in adults |
| title_sort | associations between exposure to volatile organic compounds with obesity in adults |
| topic | VOCs Obesity NHANES Qgcomp |
| url | http://www.sciencedirect.com/science/article/pii/S2666149724000586 |
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